Chronic Pain and Postoperative Cognitive Function in the Elderly: a Prospective Observational Study

Brief description of study

To assess the possible interrelation between pre-operative chronic pain and postoperative cognitive dysfunction (POCD) in the elderly, we plan to enroll patients undergoing planned surgery. To evaluate the initial pain states, pain and mood questionnaires will be used prior to surgery. To explore the potential interrelation between chronic pain and POCD, pre-, and postoperative cognitive dysfunction will be assessed using common cognitive tests. Moreover, neurocognitive biomarkers will be assessed with blood samples drawn peri- and postoperatively with optional EEG-recordings prior to and after surgery. An optional MRI will be performed in randomly assigned subjects prior to surgery.


Clinical Study Identifier: s23-00664
Principal Investigator: Jing Wang.
Other Investigators: Ricardo Miguel Osorio Suarez, Lisa V. Doan, David L Furgiuele.


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