The effect of transcutaneous auricular vagal nerve stimulation on pupillary response and perceptual learning.

Brief description of study

Study 1: We will observe the use of taVNS versus sham setting(s) on healthy human subjects and observe pupillary response in a passive study session. All subjects will receive taVNS and two sham settings (lobe stimulation and ulnar wrist stimulation) and no stimulation at all. Study 2: We will evaluate behavior on a perceptual learning in a go/no-go task paradigm where healthy human subjects will receive either taVNS, sham, or no intervention. We will also record pupil dilation on task performance to index overall effort and cognitive demand.

Clinical Study Identifier: s22-00516

ClinicalTrials.gov Identifier: NCT05386563

Principal Investigator: Mario A Svirsky.

Other Investigators: J. Thomas Roland Jr., Nicole Hope Capach.

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