Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL)

Brief description of study

The purpose of this research study is to look at the relationship between obstructive sleep apnea (OSA) and Alzheimer’s disease (AD). This is because it is shown that older adults with OSA are at increased risk for dementia and AD. This study proposes a novel and flexible approach to treating OSA in cognitively normal older adults and will test whether those successfully treated for OSA have slower decline in cognitive function, and improved AD biomarkers (measured in blood) compared to those who are untreated. The multi-modal therapy for OSA is the use of positive airway pressure, oral appliance therapy, or positional therapy, either one or a combination of the 3. We will compare 3-month changes in plasma AD biomarkers, in those randomized to OSA treatment and wait-list control groups, as well as compare change over 3 months in cognitive function between those randomized to OSA treatment and wait-list control groups, and will compare change profiles for cognition and plasma AD biomarkers in all treated (n~150) and untreated (n~100) subjects for up to 24 months of follow-up.

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