A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis

Brief description of study

The purpose of this research study is to see how safe the study drug, EXE-346, is after 4 weeks of treatment in patients with high bowel movement frequency who have undergone ileal pouch-anal anastomosis (IPAA) after colon removal (partial or full removal).

This study will last about 10 weeks and will involve about 5 visits. While in this study you will be asked to record your bowel movement frequency, take the study drug 2 times a day, and complete the in person and over the phone safety follow-ups.


Clinical Study Identifier: s23-01258
Principal Investigator: Shannon Chang.


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