ASSESSMENT OF HEMODYNAMICS SYMPTOMATOLOGY AND BIOCHEMICAL MARKERS OF NPR1 SIGNALING IN HEALTHY VOLUNTEERS AND PATIENTS WITH POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) AND PATIENTS WITH NEUROGENIC ORTHOSTATIC HYPOTENSION (NOH)

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ASSESSMENT OF HEMODYNAMICS SYMPTOMATOLOGY AND BIOCHEMICAL MARKERS OF NPR1 SIGNALING IN HEALTHY VOLUNTEERS AND PATIENTS WITH POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) AND PATIENTS WITH NEUROGENIC ORTHOSTATIC HYPOTENSION (NOH)

Brief description of study

The primary objective of the study is to assess the magnitude and variability of orthostatic hemodynamic changes in participants with POTS and in participants with nOH in a head up tilt table test (HUT). This is a non-interventional study to evaluate the performance of different hemodynamic assessments, wearable devices, biomarkers, and novel electronic clinical outcome assessments (eCOAs) in healthy participants and participants with POTS and with nOH. The study consists of a screening period, a testing period, which includes two in-clinic visits and an ambulatory period, and an end of study (EOS) visit.

Clinical Study Identifier: s23-00958

Principal Investigator: Maria Alejandra Gonzalez-Duarte Briseno.

Other Investigator: Patricio Alejandro Millar Vernetti.

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