Developing a Novel Neural marker for Assessing Pathological Social Interactions

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Developing a Novel Neural marker for Assessing Pathological Social Interactions

Brief description of study

We hypothesize that pathological social interactions like those observed in Autism, arise from a failure by patients to appropriately model the thoughts and plans of others. In a previous project (s21_00714), we designed and tested a diagnostic suite of behavioral experiments, rooted in game theory, that can rapidly characterize the depth and structure with which an individual models the thoughts and plans of others. In the current project, we aim to use these tools with functional MRI (fMRI) in humans to uncover the neural mechanism of the depth and structure with which individuals reason about other individuals. In the experiment, subjects play a series of games, in which they are asked to choose between monetary amounts, while also taking into account the choices of other participants in the study. One of these decisions is then randomly selected for realization and the subject will receive the monetary outcome they selected on that round of the game.

Clinical Study Identifier: s23-00973

Principal Investigator: Paul W. Glimcher.

Other Investigator: Vered Kurtz-David.

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