Assessing dysarthria severity before and after neurosurgical procedures: A prospective longitudinal study in patients with refractory movement disorders

Brief description of study

The purpose of this research study is to compare how an individual’s speech is impacted by high intensity focused ultrasound (HIFU) treatments and by deep brain stimulation (DBS) treatments. The study will include patients who have been diagnosed with Essential Tremor and are undergoing HIFU treatments, patients who have been diagnosed with Parkinson’s disease (PD) and are undergoing DBS surgery, as well as a group of healthy control participants who are matched in age/gender to the patient groups. Participants who have already undergone DBS surgery may also participate. This study will provide insights into the underlying nature of speech and voice changes following surgery, including possible mechanisms of action to improve it and potentially allow for better prediction of outcomes for patients dealing with speech and voice challenges related to surgery.


Clinical Study Identifier: s24-00169
Principal Investigator: Adeen Flinker.


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