Prospective Pilot Study on Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty

Brief description of study

TKA is an effective intervention for the treatment of chronic knee pain and disability in patients with knee OA. However, approximately 10% to 34% of patients experience persistent chronic pain after TKA. Persistent postsurgical pain is defined as persistent pain of at least three to six months duration that develops or increases in intensity after surgery and affects health-related quality of life. After TKA, patients with persistent pain may be disappointed with the outcome as pain severity plateaus. While the etiology of persistent pain following TKA is multifactorial, there is growing evidence that synovitis and patient-specific inflammatory response to surgery may influence the long-term clinical outcome following TKA. Over the past decade, embolization of the genicular arteries has been evaluated for the treatment of knee OA, showing significant improvement in knee pain, function, and quality of life. The goal of this proposed prospective, single-center, single-arm trial is to evaluate the safety and efficacy of GAE for treatment of persistent postsurgical knee pain following TKA.


Clinical Study Identifier: s23-00595
ClinicalTrials.gov Identifier: NCT06134817
Principal Investigator: Bedros Taslakian.
Other Investigators: Elizabeth M Morris, Shu Liu, Jonathan Samuels, Erin Fitzgerald Alaia, William B. Macaulay, Mukundan G Attur.


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