Mechanisms and Enhancement of Learning During Sleep

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Mechanisms and Enhancement of Learning During Sleep

Brief description of study

There are two major steps in learning: 1) attending to and encoding the information and 2) stabilizing or consolidating the transiently encoded information. Memory consolidation, the second stage in the learning process, is the transformation of short-term memory traces into stable long-term representations. Sleep is increasingly recognized for its critical role in consolidation, perhaps by replaying, processing, and integrating temporary memories into long-term storage. In this study, we seek to elucidate how sleep supports learning across various cognitive domains, by relating aspects of sleep architecture (eg time spent in NREM vs REM sleep, spindle frequency) and fMRI connectivity to learning outcomes.

Clinical Study Identifier: s14-00609

Principal Investigator: Anli A Liu.

Other Investigators: Werner K Doyle, Jacqueline A French, Daniel Friedman, Orrin Devinsky.

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