Effects of ondansetron in obsessive-compulsive and tic disorders
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Obsessive-compulsive DisorderChronic Tic Or Tourette Disorder
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Age: Between 18 - 60 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- You have a diagnosis of Obsessive-Compulsive Disorder (OCD) or Chronic Tic Disorder/Tourette’s Disorder (TD) according to DSM-5 criteria
- You have moderate or greater disorder severity
- You are on psychotropic medication, stable for at least 6 weeks, or you are not taking any medications
You may not be eligible for this study if the following are true:
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- You have a present or previous diagnosis of schizophrenia, bipolar disorder, or autism spectrum disorder based on DSM-5 criteria
- You have a present diagnosis of alcohol or substance use disorder (moderate or severe) based on DSM-5 criteria
- You are experiencing current moderate or high suicidality
- You have a major neurological illness (e.g., head trauma, chronic migraines, seizures, Parkinson’s disease, or other significant medical illness that would make participation unsafe or unfeasible)
- You have a health problem that prevents you from completing study procedures (e.g. back problems, severe carpal tunnel syndrome, impaired vision that is not corrected with glasses or contact lenses)
- You are a pregnant or nursing woman
- You have a positive urine toxicology or pregnancy test on the day of screening
- You have a drug allergy or known hypersensitivity to ondansetron (or other similar medications)
- You have heart disease, heart failure, heart rhythm disorder, long QT syndrome, or abnormal EKG results that the study doctor believes would make participation unsafe
- You take apomorphine or any other drug that acts similarly to ondansetron (typically other anti-nausea medications)
- You have blood test results at screening that the study doctor believes would make participation unsafe
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.