Controlling Behcet's Uveitis Through Transfer of Ex-Vivo Expanded Regulatory T Cells

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Behcet's Uveitis
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Males and females age 18 and older who fulfill the weight criteria for blood draws (110 lbs)
    3. ETHNICITY. Patients must have been born in OR have at least one parent who was born in a Behcet's high-incidence geographic region. The following geographic regions qualify: 1) Europe - only the following countries: Turkey, Portugal, Spain, Italy, Albania, Greece, or Cyprus. 2) Middle East - All countries qualify. Patients from Israel must be of either Arab or Sephari-Jewish (including Sephardic Jewish with Ashkenasi admixture) descent. Ashkenasi Jews, even if born in Israel, are not eligible, unless there is maternal Sephardic ancestry. 3) North Africa - only the following countries: Egypt, Tunisia, Libya, Algeria, Morocco. The remaining countries of the Maghreb zone (Mauritania and Western Sahara) are not eligible. 4) Central Asia - Only subjects of Central Asian descent are eligible. Subjects of Russian, Belorussian, Ukrainian or Baltic ancestry without Central Asian admixture - even if resident in the area for generations - are not eligible. 5) East Asia - All countries are eligible with the exception of all East Asian territories that are part of the Russian Federation.
    4. DIAGNOSIS OF UVEITIS. Subjects must carry a diagnosis of intermediate uveitis, and/or posterior uveitis, and/or retinal vasculitis, and/or panuveitits, determined by an ophthalmologist at any time.
    5. DISEASE ACTIVITY. Patients with all degrees of disease activity at the time of inclusion are eligible. This pertains to both, overall activity of Behcet's disease and activity of Behcet's Eye Disease (uveitis).

You may not be eligible for this study if the following are true:

    1. Concomitant autoimmune disease (with the exception of hypothyroidism due to Hashimoto's thyroiditis).
    2. Pregnant (women only)
    3. Pregnant women as well as women up to 1 month post-partum will be excluded from the study, given the volume blood drawn. Breast feeding per se does not constitute an exclusion criteria as long as the mother is at least 1 month post-partum.

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