Effects of Elevated Intraocular Pressure on Lamina Cribrosa

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
  • Age: Between 18 - 90 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    Healthy volunteers
    1. No family history (first degree relative) of glaucoma
    2. No history of IOP >22 mmHg
    3. Normal appearing optic discs and RNFL on dilated fundus examination
    4. Normal Swedish interactive thresholding algorithm (SITA) standard perimetry tests as defined by glaucoma hemifield test (GHT) within normal limits.
    Glaucoma suspects
    1. Normal visual field as defined above.
    2. Either IOP between 25 to 30 mmHg with central corneal thickness < 550 micrometer, or a difference of at least 0.2 in cup to disc ratio between eyes.
    Subjects with glaucoma
    1. IOP or cup to disc ratio as defined for glaucoma suspects
    2. Two consecutive abnormal SITA standard perimetry tests with GHT outside normal limits.

You may not be eligible for this study if the following are true:

    1. Media opacity (e.g. lens, vitreous, cornea) that prevents acquisition of good quality scans.
    2. Strabismus, nystagmus or a condition that would prevent acquisition of good quality scans.
    3. Diabetes with evidence of retinopathy.
    4. Previous intraocular surgery or ocular trauma (with the exception of laser procedures and subjects that have undergone uneventful cataract surgery more than 6 months from enrollment date).
    5. Neurological and non-glaucomatous causes for visual field damage.
    6. Any intraocular non-glaucomatous ocular disorders.

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

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