Clinical Research Studies

The pathogenesis of type 1 diabetes is still incompletely understood. Markers of autoimmunity and immunologic changes occur prior to the development of elevated blood sugar levels. A significant amount of insulin production remains at diagnosis and slowly decreases over time. If we can better understand the processes involved in the evolution of insulin deficiency, we may be able to provide a mechanism through which we can slow or stop beta cell destruction. The New York University (NYU) Pediatric Diabetes Database and Biobank Study aims to: 1) Maintain a database from which clinical questions may be answered in the future 2) Examine the rate of loss of beta cell function in subjects diagnosed with diabetes 3) Examine the rate of loss of beta cell function in relatives of subjects diagnosed with diabetes 4) Examine the role of the microbiome in the development of diabetes in children 5) Identify environmental biomarkers present in serum and urine 6) Create a resource to facilitate biomedical research within and without the NYULMC community 7) Examine the above in relation to cytokine production 8) Examine the above in relation to T-cell function