Modulating movement intention via cortical stimulation in healthy subjects and patients with psychogenic movement disorders and non-epileptic seizures
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Psychogenic Movement Disorder
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Age: Between 18 - 65 Years
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Gender: Male or Female
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Other Inclusion Criteria:
Healthy Subjects:- Subjects between the ages of 18 and 65 years
- Subjects with Score at least 25 out of 30 on the MOCA
- Subjects who are right-handed in most cases, except when serving as controls for left-handed patients
- Subjects who are fluent in English
- Subjects between the ages of 18 and 65 years
- Subjects with Score at least 25 out of 30 on the MOCA
- Subjects who are fluent in English
- Subjects with the clinical assesment requirements of PMD or PNES diagnosis reviewed and confirmed by a certified physician
- Subjects who are unlikely to require treatment and/or dosage changes for 3-6 months following screening
You may not be eligible for this study if the following are true:
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Healthy Subjects:
- Subjects with any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the PI
- Subjects with chronic or progressive medical condition
- Subjects who have any history of traumatic brain injury or significant head trauma
- Subjects currently meets criteria for substance abuse or dependence
- Subjects with history of any psychotic disorder or other psychiatric condition which may interfere with data interpretation
- Subjects who are pregnant
- Subjects with metal or devices in the head, including neurostimulators or metal foreign bodies
- Subjects with any other implanted metal device, including pacemaker, spinal cord stimulator, VNS.
- Subjects with any other ferromagnetic substance in the body that may increase study risk
- Subjects who are taking tricyclic antidepressant or antiepileptic medications or CNS active drugs under “strong potential hazard” list in Rossi et al., 2009
- Subjects who have current diagnosis of any inflammatory or autoimmune disorder within last 6 months
- Subjects who have any history of traumatic brain injury or significant head trauma
- Subjects with diagnosis of organic seizure disorder, including febrile seizures and tonic-clonic seizures
- Subjects who have neurological disorder other than PMD and PNES including stroke, fainting spells or syncope of unknown cause(s)
- Subjects with major or unstable medical illness
- Subjects who have metal or devices in the head, including neurostimulators or metal foreign bodies
- Subjects who are taking tricyclic antidepressant or antiepileptic medications or CNS active drugs under “strong potential hazard” list in Rossi et al., 2009
- Subjects with diagnosis of dementia, or Montreal Cognitive Assessment (MoCA) =24
- Subjects with recurrent visual hallucinations, within the past 6 months
- Subjects have history of significant uncontrollable movements of the head
- Subjects with any clinically significant abnormality on vital signs
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