The effect of Transjugular Intraheptic Portosystemic Shunt (TIPS) on gastrointestinal motility and the gut microbiota.

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Cirrhosis
  • Age: Between 18 - 99 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Patients with a confirmed diagnosis of either cirrhotic portal hypertension or non-cirrhotic portal hypertension.
    2. Patients undergoing an elective TIPS for any standard of care established indication (examples: worsening ascites, recurrent variceal bleeding).

You may not be eligible for this study if the following are true:

    1. Age less than 18 years.
    2. Pregnant women.
    3. Patients unwilling or unable to provide informed consent.
    4. Patients undergoing an emergent TIPS for acute or subacute variceal hemorrhage.
    5. Patients with diseases that directly and significantly affect intestinal motility
    6. Previously diagnosed gastroparesis or other GI dysmotility disorder.
    7. Patients currently taking narcotics, antibiotics excluding rifaximin, prokinetic medications or lactulose.
    8. Patients with a history of gastric bezoar.
    9. Patients with a history of multiple intestinal surgeries or GI surgery within the past 3 months.
    10. Patients with a history of gastrointestinal strictures, fistulas, or physiological or mechanical obstruction.
    11. Patients with a history of Crohn disease.
    12. Patients with a history of diverticulitis.
    13. Patients with swallowing disorders and increased risk of aspiration (such as prior history of aspiration).
    14. Patient with Celiac disease.
    15. Patients with implanted or portable electro-mechanical medical devices.



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