Sleep Aging and Risk for Alzheimer's

Brief description of study

Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline. In this study, we will extend our prior work using home-sleep monitoring and cerebrospinal fluid collection in normal older adults by directly interrogating the brain using 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at 24 month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, of whom can profit the most from sleep preventive strategies.




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