Comparative Effectiveness of Pulmonary Embolism Prevention after hiP and kneE Replacement (PEPPER): Balancing Safety and Effectiveness
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Total Knee ArthroplastyTotal Hip Arthroplasty
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Age: Between 21 - 95 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- Undergoing elective primary or revision hip or knee replacement
- Patient has necessary mental capacity to participate and is able to comply with study protocol requirements
- Patient is willing and able to give consent and participate
- Patient is willing and able to be randomized
You may not be eligible for this study if the following are true:
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- No patient undergoing total hip or knee replacement who has been enrolled in this study for a prior hip or knee replacement can be enrolled for a second hip or knee replacement in this study.
- No patient that is currently actively enrolled in another clinical trial may be enrolled in this study.
- Women who are pregnant or breastfeeding, as well as those of reproductive potential unless there is a negative urine pregnancy test.
- Patients on chronic (longer than the prior 6 months) anticoagulation other than with antiplatelet medications 4) Documented gastrointestinal, cerebral, or other hemorrhage within 3 months of the operation
- A prior episode of hypersensitivity or adverse reaction to heparin
- A known diagnosis of defective hemostasis
- Within one month of an operative procedure involving the eye, ear, or central nervous system
- Severe uncontrolled hypertension with systolic BP > 220mmHg and diastolic BP > 120mmHg
- An absolute body weight of less than 41 kilograms (90.4 lbs) on day of enrollment
- Vulnerable patient populations including prisoners and institutionalized individuals
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.