Comparative Effectiveness of Pulmonary Embolism Prevention after hiP and kneE Replacement (PEPPER): Balancing Safety and Effectiveness

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Total Knee Arthroplasty
    Total Hip Arthroplasty
  • Age: Between 21 - 95 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Undergoing elective primary or revision hip or knee replacement
    2. Patient has necessary mental capacity to participate and is able to
    3. comply with study protocol requirements
    4. Patient is willing and able to give consent and participate
    5. Patient is willing and able to be randomized

You may not be eligible for this study if the following are true:

    1. No patient undergoing total hip or knee replacement who has been enrolled in this study for a prior hip or knee replacement can be enrolled for a second hip or knee replacement in this study.
    2. No patient that is currently actively enrolled in another clinical trial may be enrolled in this study.
    3. Women who are pregnant or breastfeeding, as well as those of reproductive potential unless there is a negative urine pregnancy test.
    4. Patients on chronic (longer than the prior 6 months) anticoagulation other than with antiplatelet medications 4) Documented gastrointestinal, cerebral, or other hemorrhage within 3 months of the operation
    5. A prior episode of hypersensitivity or adverse reaction to heparin
    6. A known diagnosis of defective hemostasis
    7. Within one month of an operative procedure involving the eye, ear, or central nervous system
    8. Severe uncontrolled hypertension with systolic BP > 220mmHg and diastolic BP > 120mmHg
    9. An absolute body weight of less than 41 kilograms (90.4 lbs) on day of enrollment
    10. Vulnerable patient populations including prisoners and institutionalized individuals



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