Reversing Diabetic Peripheral Neuropathy Through Exercise

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Reversing Diabetic Peripheral Neuropathy Through Exercise

Brief description of study

This cross-over design study proposes an innovative multinuclear MRI approach to gain mechanistic insight into the exercise-associated adaptations in lower leg muscle function and peripheral nerve integrity of patients with diabetic peripheral neuropathy (DPN). Currently, there are no therapies to prevent or reverse the progress of DPN. Our team is uniquely positioned to use novel multinuclear MRI technology to understand how exercise affects skeletal muscle and peripheral nerve integrity and function in patients with DPN. We will prescribe a 4-week non-exercise phase followed by a 10-week exercise program (with both aerobic and strengthening components) to 40 DPN patients who will receive personal supervision from health professionals.

Clinical Study Identifier: s18-00527

ClinicalTrials.gov Identifier: NCT03686423

Principal Investigator: Ryan Brown.

Other Investigators: Smita Rao, James S Babb, Steven H. Baete.

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