Modifiable cardiovascular factors linking type 2 diabetes and Alzheimer's disease

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Modifiable cardiovascular factors linking type 2 diabetes and Alzheimer's disease

Brief description of study

Millions of Americans have Alzheimer’s disease (AD). Type 2 diabetes (T2D) leads to a near doubling of the risk of dementia and the two conditions share similar brain impairments. Cerebrovascular risk factors may be the link between the two conditions. Thus, understanding the impact of T2D on the brain will be informative for future AD prevention strategies targeting those risk factors. We will test how large weight loss and improvement in the cerebrovascular modifiable factors from bariatric surgery of individuals with T2D leads to brain improvement and how this recovery is tempered by sex, education, and fitness.

Clinical Study Identifier: s17-01236

Principal Investigator: Antonio J Convit.

Other Investigators: Ricardo Miguel Osorio Suarez, Henry Rusinek, Holly F Lofton.

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