An observational study assessing the prevalence of lumbosacral spinal urate deposition in patients with tophaceous and non-tophaceous gout compared with non-gout controls using Dual-Energy CT (DECT)

Brief description of study

The purpose of this study is to assess the prevalence and extent of uric acid deposits in the lower (lumbosacral) spine of people with gout, compared to individuals without gout. Uric acid is a byproduct when the body breaks down substances called purines, which are found in the body naturally and in some foods and drinks. Patients with gout typically have crystals of uric acid deposited in and around the joints and tendons of their hands and feet, but whether uric acid is also deposited in the joints of the spine is not definitively known. The study will involve the use of a new type of computed tomography (CT) scan called a dual-energy CT (DECT). DECT is an FDA-approved diagnostic tool currently used in clinical settings. In addition, the study will look at whether uric acid in the spine is associated with chronic low back pain.


Clinical Study Identifier: s18-00588
Principal Investigator: Michael H Pillinger.


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