A single center pilot study to assess the intra-observer reliability of measuring muscle strength using a hand held dynamometer in children and adults with neurofibromatosis type 1 (NF1) and type 2 (NF2)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Nf1 Or Nf2
  • Age: Between 5 years - 100 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    For Cohort 1
    1. Subjects are at least 5 years old
    2. Subjects must have clinically confirmed NF1 using the NIH consensus criteria or a known NF1 mutation.
    3. Subjects have have <5/5 strength on MMT testing (in at least one muscle group)
    4. Subjects able to follow instructions and cooperate with exam to assess strength
    For Cohort 2
    1. Subjects are at least 5 years old
    2. Subjects must have clinically (NIH or Manchester criteria) or genetically confirmed diagnosis of NF2
    3. Subjects have <5/5 strength on MMT testing (in at least one muscle group)
    4. Subjects able to follow instructions and cooperate with exam to assess strength

You may not be eligible for this study if the following are true:

    1. Subjects with no orthopedic procedure or other major surgery that could influence extremity strength in past 6 months
    2. Subjects with no tibial dysplasia



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.