AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Embolic Stroke Of Undetermined Source
  • Age: Between 45 - 999 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Subjects who are =45 years.
    2. Subjects clinically diagnosed with ischemic stroke + brain imaging to rule out hemorrhagic stroke
    3. Subjects with Modified Rankin Scale (MRS) score =4.
    4. Subjects with the ability to be randomized no later than 120 days after stroke onset
    5. Subjects with Embolic stroke of undetermined source as per the protocol

You may not be eligible for this study if the following are true:

    1. Subjects with history of AF, AF on 12-lead ECG, or any AF of any duration during heart-rhythm monitoring prior to randomization.
    2. Subjects with clear indication for treatment-dose anticoagulant therapy
    3. Subjects who had Left ventricular ejection fraction <30%
    4. Subjects with definite indication for antiplatelet agent
    5. Subjects with history of spontaneous intracranial hemorrhage
    6. Subjects with chronic kidney disease with serum creatinine =2.5 mg/dL
    7. Subjects with clinically significant bleeding diathesis.
    8. Subjects with chronic anemia (hemoglobin <9 g/dL) or thrombocytopenia
    9. Subjects with GI bleeding within the past year considered clinically significant
    10. Female subjects who are pregnant or sexually active without the use of highly effective contraception
    11. Subjecy with known allergy or intolerance to aspirin or apixaban.
    12. Subjects are concomitantly participating another clinical trial involving a drug or acute stroke intervention.
    13. Subjects who are considered by the investigator to have a condition that precludes follow-up or safe participation in the trial
    14. Subjects who are unable to provide written, informed consent



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