In vivo insights of small vessel changes with age using ultra-small-superparamagnetic-iron-oxide (USPIO)-enhanced MRI

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Vascular Pathology
  • Age: Between 18 Year(s) - 85 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Subjects who are between the ages of 18 and 85 years old
    2. Subjects who are free of cardiovascular, metabolic and neurological diseases as well as high risk factors of vascular diseases
    3. Subjects who are willing to participate and able to complet the study
    4. Subjects have no contraindication to MRI/Contrast agent

You may not be eligible for this study if the following are true:

    1. Subjects with electrical implants such as cardiac pacemakers or perfusion pumps
    2. Subjects who have ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants (CVD)
    3. Subjects who have claustrophobia
    4. Subjects with history of seizures
    Exclusion criteria for Ferumoxytol injection:
    1. Subjects who are pregnant or breastfeeding
    2. Subjects who have a history of iron overload diseases such as Hemochromatosis or thalassemia
    3. Subjects with Cirrhosis
    4. Subjects who had blood transfusion within the previous 2 months
    5. Subjects who had major surgery within the previous month
    6. Subjects with anemia not caused by iron deficiency
    7. Subjects who used parenteral or oral iron therapy within the previous 2 weeks, unless further administration of Ferumoxytol is clinically indicated
    8. Subjects with known hypersensitivity to Ferumoxytol or any of its components
    9. Subjects who have history of allergic reaction to any intravenous iron product
    10. Subjects with scheduled diagnostic MRI with contrast (unrelated to the present study) within the following 4 weeks
    11. Subjects who are unable to read and sign an informed consent
    12. Subjects with chronic back pain or inability to lie still for 30 minutes or more

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