Identify predictors that distinguish between Tofacitinib responders and non-responders based on genotype and cellular and molecular profiles from pinch biopsies blood and stool samples

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Ulcerative Colitis
  • Age: Between 18 - 70 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Subjects who are between the ages of 18 and 70 years old
    2. Subjects who have moderate to severe ulcerative colitis
    3. Subjects who will have a colonoscopy will be performed within 3 months of starting tofacitinib therapy, as part of standard of care.

You may not be eligible for this study if the following are true:

    1. Subjects who have recent use of antibiotic therapy (<4 weeks).
    2. Subjects who have currently an extreme diet (parenteral nutrition, specific carbohydrate diet).
    3. Subjects who are on biologic or immunosuppressive therapy within 4 weeks.
    4. Subjects who have an active infection or malignancy
    5. Subjects who have significant underlying liver or renal disease

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.