Use of postoperative antibiotics in endoscopic sinus surgery: A multi-institutional prospective randomized controlled trial
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Sinonasal
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Age: Between 18 years - 99 years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subjects willing to complete all study specific procedures and visits and complete the consent form
- Subjects diagnosed with chronic rhinosinusitis (CRS) with or without nasal polyposis or allergic fungal rhinosinusitis
- Subjects who are at least 18 years old
- Subjects will are potential candidates for Endoscopic sinus surgery (ESS)
You may not be eligible for this study if the following are true:
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- Subjects with sinonasal tumors
- Subjects who have allergy to penicillin
- Subjects with history of intra-abdominal abscess or diverticulitis or have history of infectious (bacterial, viral, fungal, parasitic, etc.) colitis
- Subjects who have adverse reactions to amoxicillin-clavulanate or penicillin
- Subjects who have immunodeficiency
- Subjects who have cystic fibrosis
- Subjects who are pregnant or lactating
- Subjects with diabetes with nasal polyposis
- Subjects undergoing active treatment for malignancy
- Subjects with previous treatment with investigational agents
- Subjects who lack the capacity to consent
- Subjects undergoing unilateral ESS or with nonabsorbable packing placed at the time of surgery
- Subjects who are on antibiotics
- Subjects with acute on chronic sinusitis or the presence of purulence at time of surgery
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.