Pilot Study to evaluate glycemic variability measured by continuous glucose monitoring in high-risk individuals with normal hemoglobin A1c levels (HbA1c
Brief description of study
Screening for glucose disorders may underestimate the prevalence of dysglycemia in individuals with a normal HbA1c (< 5.7%) at high-risk for progression to type 2 diabetes (T2DM) [presence of one or more of the following: overweight, obesity, polycystic ovarian syndrome (PCOS), fatty liver (NAFLD), metabolic syndrome (MS), hypertension, primary family history of diabetes, or history of gestational diabetes (GDM)]. Subjects will undergo an oral glucose tolerance test (OGTT) and wear a subcutaneous continuous glucose monitoring (CGM) sensor for 14 days that can detect dysglycemia and glycemic variability (GV) which has been associated with vascular damage and mortality.
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