A Single-Center Observational Longitudinal Study on the Effect of Slow Wave Sleep (SWS) Characteristics and Race and Ethnicity on Amyloid Burden (A Marker of Alzheimer s Disease Risk) among cognitively normal elderly

Brief description of study

Sleep AWARE is a research study funded by the National Institutes of Health and the National Institutes for Aging. We will examine how race, genes, and other factors influences an individual’s risk for developing Alzheimer’s disease (AD). Poor sleep is thought to contribute to increased risk for developing AD. African Americans in particular have lower quality sleep and less sleep duration and thus may be at greater risk for AD. Researchers hope to compare sleep characteristics and their effects on Alzheimer’s disease risk among African Americans and non-Hispanic Whites. You may be eligible if you are between the ages of 60 and 75 and you identify as Non-Hispanic White or African American.

If you are eligible, you will be asked to participate in four to six baseline visits, a one-year follow up, and four to six follow-up visits after two years.

  1. Your first and second visit will require a medical and medications history report, a clinical evaluation memory testing and blood draw
  2. Your third visit will be the remainder of your cognitive testing, blood work, and a sleep interview
  3. Your fourth visit will consist of a one night sleep study at Mount Sinai Integrative Sleep Center
  4. Your fifth visit will include a PET-MR scan
  5. You will be compensated for your participation in this study


Clinical Study Identifier: s18-01302
ClinicalTrials.gov Identifier: NCT03814603
Principal Investigator: Ricardo Miguel Osorio Suarez.
Other Investigators: James S Babb, Esther Blessing, Omonigho Michael Bubu, Arjun V. Masurkar, Alcibiades J Rodriguez, Karyn D Marsh, Arline Faustin, Timothy Michael Shepherd, Girardin Jean-Louis, Els Diane Tonia Fieremans.


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