A SINGLE-CENTER OBSERVATIONAL LONGITUDINAL STUDY ON THE EFFECT OF SLOW WAVE SLEEP (SWS) CHARACTERISTICS AND RACE AND ETHNICITY ON AMYLOID BURDEN (A MARKER OF ALZHEIMER S DISEASE RISK) AMONG COGNITIVELY NORMAL ELDERLY.

Brief description of study

African-Americans (AAs) have an increased prevalence of both Alzheimer’s disease (AD) and vascular risk factors for AD such as diabetes and hypertension when compared to whites. This larger component of AD-dementia has traditionally been associated with vascular risk and supported by studies showing that AAs with clinical AD more frequently have mixed pathology on autopsy. However, in a recent community based study of non-demented elderly, black race was associated with higher amyloid burden after adjusting for vascular risk factors, suggesting the presence of additional physiological differences on AD-risk by race in the early stages of the disease. The purpose of this study is to test whether poor slow wave sleep (SWS) quantity (SWS duration) and quality (slow wave activity, SWA) is one of these physiological factors.


Clinical Study Identifier: s18-01302
ClinicalTrials.gov Identifier: NCT03814603
Principal Investigator: Ricardo Miguel Osorio Suarez.
Other Investigators: James S Babb, Esther Blessing, Omonigho Michael Bubu, Arjun V. Masurkar, Alcibiades J Rodriguez, Karyn D Marsh, Arline Faustin, Timothy Michael Shepherd, Girardin Jean-Louis, Els Diane Tonia Fieremans.


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