THE ROLE OF THE MICROBIOME IN MONOZYGOTIC TWINS WITH PSORIASIS AND PSORIATIC ARTHRITIS

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THE ROLE OF THE MICROBIOME IN MONOZYGOTIC TWINS WITH PSORIASIS AND PSORIATIC ARTHRITIS

Brief description of study

We propose a longitudinal study of monozygotic twins discordant for psoriatic disease. Subjects will be characterized with detailed clinical questionnaires in addition to blood, fecal, skin swab, skin biopsy (optional) and urine (optional) specimen collections. These will be used to perform microbiome analysis and explore markers of inflammation as well as immunologic parameters. Healthy and psoriasis (not psoriatic arthritis) twins will be followed for up to five years. Data and biospecimen collections will be repeated on an annual basis or earlier in the case of disease conversion.

Clinical Study Identifier: s18-00742

Principal Investigator: Jose U Scher.

Other Investigators: Rebecca Haberman, Sergei B Koralov, Avrom S Caplan, Rebecca Barbara Blank, Shruti Naik, Andrea L. Neimann.

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