THE ROLE OF THE MICROBIOME IN MONOZYGOTIC TWINS WITH PSORIASIS AND PSORIATIC ARTHRITIS

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THE ROLE OF THE MICROBIOME IN MONOZYGOTIC TWINS WITH PSORIASIS AND PSORIATIC ARTHRITIS

Brief description of study

Psoriasis is a chronic immune-mediated skin condition that often presents with plaques on the skin. Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Approximately a third of patients who have psoriasis later develop psoriatic arthritis. The purpose of this study is to explore why people get psoriatic disease and why some progress from having disease of the skin (psoriasis) to having disease in the joints (psoriatic arthritis). For this study, the researchers are particularly interested in the role that the human microbiome plays in developing psoriasis and psoriatic arthritis. The study will try to answer this question by collecting blood, stool, skin swab, and optional urine and skin biopsy samples, in addition to a clinical questionnaire. The samples collected will allow the researchers to study the causes of psoriatic disease, why it gets worse in certain individuals, and what protects other individuals from getting the disease or from progressing.

Clinical Study Identifier: s18-00742

Principal Investigator: Jose U Scher.

Other Investigators: Shruti Naik, Sergei B Koralov, Avrom S Caplan, Rebecca Barbara Blank, Rebecca Haberman, Andrea L. Neimann.

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