A Randomized Double-Blind Multi-Center Open-Label Effectiveness Trial of Antidepressant Augmentation in Patients with Treatment Resistant Depression
Brief description of study
The purpose of this research to compare three treatment strategies for patients with Treatment Resistant Depression (TRD): adding the atypical antipsychotic aripiprazole to current antidepressant treatment, adding repetitive transcranial magnetic stimulation (rTMS) to current antidepressant treatment, and switching to the serotonin-norepinephrine reuptake inhibitor (SNRI) venlafaxine extended release or duloxetine for those who have already tried venlafaxine extended release. Repetitive TMS is a way to stimulate parts of the brain with a series of magnetic pulses. It’s non-invasive and the magnetic pulses are painless. All three of these treatments are FDA-approved for major depression, widely available and commonly used in TRD. They are either generic, or covered by Medicare and commercial insurance.
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