Prospective Multicenter Clinical Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients

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Prospective Multicenter Clinical Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients

Brief description of study

The purpose of this study is to demonstrate the effectiveness of Riociguat as replacement of PDE-5i therapy (Sildenafil or Tadalafil) in patients with pulmonary arterial hypertension (PAH) who are on a stable dose of phosphodiesterase-5 inhibitors (PDE-5i: Sildenafil or Tadalafil) with or without endothelin receptor antagonist (a drug that blocks endothelin receptors), but the treatment has not reached its goal. Riociguat (Brand name: Adempas) is approved by Health Authorities including the FDA (Food and Drug Administration) for the treatment of Pulmonary arterial hypertension.

Clinical Study Identifier: s18-02027

Principal Investigator: Sapna Mehta.

Other Investigators: Robert Montgomery, Bruce E Gelb, Elaina Weldon, Matthew C. Ringer, Henry J. Neumann, Pauline Labella, Bonnie Elizabeth Lonze, Virginie S. Halpern-Cohen, Vasishta Tatapudi, Fainareti Zervou.

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