A randomized double-blind placebo-controlled twocohort parallel group study to evaluate the efficacy of CAD106 and BACE-1 INHIBITOR in preclinical Alzheimer s disease participants at risk for the onset of clinical symptoms
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Alzheimer Disease
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Age: Between 60 - 75 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subjects who provide written informed consent must be obtained before any assessment
- Subjects who are between the ages of 60-75 years old
- Subjects does not meet criteria for dementia
- Subjects does not meet criteria for MCI due to AD as defined by the protocol
- Subjects having an identified study partner acting as informant who is willing to participate as a source of information and has at least weekly contact with the participant
- Subjects and their study partners who have adequate functioning and fluent in and able to read
You may not be eligible for this study if the following are true:
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- Subjects with any social or medical problem that precludes compliance with the protocol
- Subjects with history in the past two years or current diagnosis of CNS inflammation indicative of meningoencephalitis or another concurrent disease
- Subjects with history of stroke
- Subjects with history within the past 2 years or current DSM-IV diagnosis of major depression and/or any other DSM-IV Axis 1 diagnosis that may interfere with the evaluation of the participant’s response to study medication, including primary neurodegenerative dementia, schizophrenia, or bipolar disorder.
- Subjects with current diagnosis of an active seizure disorder, whether controlled or not.
- Women of child-bearing potential and not considered post-menopausal unless they have had 12 months of natural amenorrhea with an appropriate clinical profile or have had surgical bilateral oophorectomy or tubal ligation at least six weeks prior to screening.
- Subjects who have coronary heart disease
- Subjects with uncontrolled hypo- or hypertension
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.