Imaging biomarkers of knee osteoarthritis

Brief description of study

The purpose of this study is to develop a non-invasive way (non-invasive meaning that no medical instruments will breach your skin) of taking pictures using an Magnetic Resonance Imaging (MRI) that can help identify the early stages of osteoarthritis (OA) in the knees and predict OA progression. In addition to develop highly accelerated imaging sequences for ex-vivo knee OA applications on a standard clinical 3T scanner using novel CS and parallel imaging (PI) strategies. Use the study's imaging techniques in-vivo to determine whether the accelerated baseline imaging biomarkers will predict incident OA, OA progression and worsening of clinical outcomes (pain, function scores) over24 months


Clinical Study Identifier: s16-00918
ClinicalTrials.gov Identifier: NCT02888119
Principal Investigator: Ravinder R Regatte.


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