A prospective randomized international multicenter double-arm controlled open-label study of Riociguat in patients with pulmonary arterial hypertension (PAH) who are on a stable dose of phosphodiesterase-5 inhibitors (PDE-5i) with or without endothe
Brief description of study
The purpose of this study is to demonstrate the effectiveness of Riociguat as replacement of PDE-5i therapy (Sildenafil or Tadalafil) in patients with pulmonary arterial hypertension (PAH) who are on a stable dose of phosphodiesterase-5 inhibitors (PDE-5i: Sildenafil or Tadalafil) with or without endothelin receptor antagonist (a drug that blocks endothelin receptors), but the treatment has not reached its goal. Riociguat (Brand name: Adempas) is approved by Health Authorities including the FDA (Food and Drug Administration) for the treatment of Pulmonary arterial hypertension.
Clinical Study Identifier: s17-01051
ClinicalTrials.gov Identifier: NCTs17-01051
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