A Phase 1 Randomized Double-blind Placebo-controlled Single Ascending Dose Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a

Brief description of study

This research study is being conducted to learn more about the effects of a new therapy, AMG 890. In animals, AMG 890 lowered the levels of Lp(a) in the blood, and it is being investigated for the treatment of cardiovascular disease. The purpose of this study is to obtain initial information on the safety and tolerability, pharmacokinetics, and pharmacodynamics of a single dose of AMG 890 in participants with elevated levels of Lp(a) in the blood. AMG 890 is being developed by Amgen Inc., a for-profit biopharmaceutical company. AMG 890 is experimental, which means it is not approved by the US Food and Drug Administration (FDA).


Clinical Study Identifier: s19-00369
ClinicalTrials.gov Identifier: NCT03626662
Principal Investigator: Howard Weintraub.


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