MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA
Brief description of study
This is a prospective, observational, proof-of-principle study looking at the effects of the gut microbiome on the metabolism and response to methotrexate treatment and related medications. Drug-naïve RA patients who will be receiving MTX as part of their standard - of-care treatment plan and who have active disease and have not received other diseasemodifying therapies (as defined by the inclusion/exclusion criteria) will be enrolled. If during the course of the study, the subject is no longer receiving MTX as part of their standard of care treatment, the subject will still complete the remainder of the study visits to understand variations in microbiome after discontinuation of MTXThe purpose of this research is to study the changes in the human microbe (bacteria in your gut/intestines) in response to methotrexate (MTX) medication.
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