MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Rheumatoid Arthritis
  • Age: Between 18 - 90 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Subjects and caregivers who can provide written signed and dated consent form
    2. Subjects are at least 18 years old
    3. Fulfillment of NORA definition: any adult patient with active, new onset RA fulfilling 2010 ACR/EULAR criteria (symptoms duration <6 months and treatment naïve).
    4. Subjects who are willing and able to provide written informed consent prior to any study specific procedures

You may not be eligible for this study if the following are true:

    1. Subjects currently (within 3 months of screening) treated with DMARDs
    2. Subjects currently (within 3 months of screening) treated with biologic therapies (including but not limited to anti-TNF, anti-IL-6 and anti-CD20)
    3. Subjects who has current antibiotic treatment (within 3 months of screening)
    4. Subjects who has current consumption of probiotics (within 3 months of screening).
    5. Subjects with severe hepatic impairment (eg, ascites and/or clinical signs of coagulopathy)
    6. Subjects who have inability of the patient to comply with study procedures and/or follow-up
    7. Subjects who are pregnant or breastfeeding



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