16 "COVID-19" clinical trials found.
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A Multicenter Adaptive Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There are no approved medicines to treat COVID-19. ...
Phase
Interventional
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An Adaptive Phase 2/3 Randomized Double-Blind Placebo-Controlled Study Assessing Efficacy and Safety of Sarilumab for Hospitalized Patients with COVID-19
The main purpose of this study is to determine if sarilumab is safe and if it can decrease the amount of time someone would have ...
Phase
Interventional
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A randomized placebo-controlled safety and dose-finding study for the use of the IL-6 inhibitor clazakizumab in patients with life-threatening COVID-19 infection
The purpose of this research study is to investigate the safety of treatment with an investigational drug called clazakizumab compared to a placebo (inactive substance) ...
Phase
Interventional
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Emergency Hyperbaric Oxygen for Respiratory Distress or Failure for COVID-19 Patients
The purpose of this study is to investigate the use of hyperbaric oxygen therapy to treat respiratory distress in patients who have tested positive for ...
Phase N/A Interventional
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A Multicenter Randomized Controlled Trial on Safety and Efficacy of Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Adults and Children
The purpose of this study is to determine if the drug hydroxychloroquine is safe for use in humans with COVID-19 and if it works as ...
Phase N/A Interventional
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Off label study to evaluate the efficacy of Hydroxychloroquine for pre-exposure prophylaxis (PrEP) to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Health Care Workers who are high Risk of Occupational Exposure to SARS-CoV-2
The Pre-exposure Prophylaxis (PrEP) Study, single, open and off label intervention study. 350 participants will be assigned to group that takes HCQ or group that ...
Phase N/A Interventional
Accepts Healthy Volunteers
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COLCHICINE CORONAVIRUS SARS-CoV2 TRIAL (COLCORONA)
COVID-19 is due to an infection by the beta-coronavirus SARS-CoV2. This will be a randomized, double-blind, placebo-controlled study. Following signature of the informed consent form, ...
Phase
Interventional
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COVID 19 Intervention: Influence of ECMO on Cytokine Storm with/without Cytokine Filtration
Approximately 8-10% of ventilator dependent patients are being placed on ECMO (extracorporeal membrane oxygenation) for adult respiratory distress syndrome during the COVID 19 pandemic. The ...
Phase N/A Match Level: Free text
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A Randomized Trial of Anticoagulation Strategies in COVID-19:PROTECT-COVID 19
Anticoagulation medicines are used to reduce the risk of blood clot formation in the blood vessels. Blood clots that form in blood vessels can travel ...
Phase
Interventional
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Efficacy of Hydroxychloroquine for Post-exposure Prophylaxis (PEP) to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Adults Exposed to Coronavirus Disease (COVID-19): a Blinded Randomized Study
The purpose of this study is to understand if taking a malaria, autoimmunity, and arthritis medication called hydroxychloroquine can reduce the risk of becoming infected ...
Phase
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