12 clinical trials found.
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A Randomized Double-Blind Placebo-Controlled Phase 2 Study Comparing the Efficacy and Safety of Tirzepatide versus Placebo in Patients with Nonalcoholic Steatohepatitis (NASH)
This study will examen whether the investigational drug, tirzepatide, is safe and able to help study participants with nonalcoholic steatohepatitis (NASH). “Investigational” means that the ...Phase
TRIAL ROLE: Principal Investigator
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A Double-Blind Randomized Placebo-Controlled Study and Open-Label Long Term Extension of study drug in Patients with Primary Biliary Cholangitis with Inadequate Response or Intolerance to Ursodeoxycholic Acid
The main purpose is to study the effect of daily oral administration of 80 mg elafibranor on cholestasis (impairment of bile formation and/or bile ...Phase
TRIAL ROLE: Principal Investigator
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ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)
The purpose of this research study is to evaluate the long-term safety and tolerability of seladelpar in treating PBC patients. Primary Biliary cholangitis (PBC) is ...Phase
TRIAL ROLE: Principal Investigator
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Efficacy and Safety of Lambda in Patients with Chronic Hepatitis Delta Virus (HDV) Infection (LIMT 2)
This is a study of an investigational drug (also known as the “study drug”) called Peginterferon Lambda-1a (Lambda) as a possible treatment for chronic hepatitis ...Phase
TRIAL ROLE: Principal Investigator
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A Phase 2a Double-Blind Randomized Active Controlled Parallel Group Study Evaluating the Efficacy Safety and Tolerability of Bezafibrate Administered in Combination with Obeticholic Acid in Subjects with Primary Biliary Cholangitis
The main purpose of this study is to assess the effects of the combination of a drug called Obeticholic Acid (OCA) and two different doses ...Phase
TRIAL ROLE: Principal Investigator
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A two-part randomized placebo controlled double blind multicenter Phase 3 study to evaluate the efficacy and safety of linerixibat for the treatment of cholestatic pruritus in participants with primary biliary cholangitis (PBC) (GLISTEN)
The purpose of this study is to further test an investigational drug called linerixibat (also referred to as GSK2330672) for the treatment of cholestatic pruritus ...Phase
TRIAL ROLE: Principal Investigator
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The Effect of Semaglutide in Non-Cirrhotic Non-Alcoholic Steatohepatitis
We are doing this study to see if the medicine called semaglutide can help patients with NASH get better and reduce their risk of future ...Phase
TRIAL ROLE: Principal Investigator
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A Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Effect of Resmetirom on Liver-related Outcomes in Patients with Well-compensated (Child-Pugh A) Non-alcoholic Steatohepatitis (NASH) Cirrhosis
A Randomized Double-blind Placebo-controlled study to determine the effect of randomized, once-daily, oral administration of 80 mg resmetirom versus matching placebo on patients with well-compensated ...Phase
TRIAL ROLE: Principal Investigator
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TRANSFORM: A 52-week Randomized Placebo-controlled Double-blind Adaptive Phase 2b/3 Trial of Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness
Calliditas Suisse SA (the Sponsor) is conducting a clinical research study to see if an experimental medicine named setanaxib, will help in the treatment of ...Phase
TRIAL ROLE: Principal Investigator
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A Phase II Multicenter Double-Blind Randomised Placebo-Controlled Study and Open-Label Long Term Extension to Evaluate the Safety and Efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC)
This study will evaluate the effects of elafibranor (the study drug) in participants with Primary Sclerosing Cholangitis (PSC). PSC is a rare disease of the ...Phase
TRIAL ROLE: Principal Investigator
