11 clinical trials found.
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A PHASE 1B/2A MULTICENTER OPEN-LABEL DOSEESCALATION STUDY TO DETERMINE THE MAXIMUM TOLERATED DOSE ASSESS THE SAFETY TOLERABILITY PHARMACOKINETICS AND EFFICACY OF CC-220 MONOTHERAPY AND IN COMBINATION WITH OTHER TREATMENTS IN SUBJECTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA
The purpose of this study is to test the safety and to define the appropriate dose of an investigational drug (CC-220) and an investigational combination ...Phase
Interventional
TRIAL ROLE: Principal Investigator
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Randomized Controlled Pivotal Trial of Autologous Bone Marrow Mononuclear Cells Using the CardiAMP Cell Therapy system in Patients with Post Myocardial Infarction Heart Failure (CardiAMP Heart Failure Trial)
The purpose of this study is to evaluate the CardiAMP cell therapy system as a treatment for patients with heart failure as a result of ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Randomized Phase 2 Study of CDX-1127 (Varlilumab) in Combination with Nivolumab in Patients with Relapsed or Refractory Aggressive B-cell Lymphomas
The purpose of this study is to compare the anti-lymphoma activity and possible side effects of using CDX-1127 (varlilumab) along with another immunotherapy drug, nivolumab ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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EA9161: A Randomized Phase III Study of the addition of Venetoclax to Ibrutinib and Obinutuzumab versus Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)
This study is being done to answer the following question: What are the good and bad effects of a time limited administration of a targeted ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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AN OPEN-LABEL RANDOMIZED MULTICENTER PHASE Ib/II TRIAL EVALUATING THE SAFETY TOLERABILITY PHARMACOKINETICS AND EFFICACY OF MOSUNETUZUMAB (BTCT4465A) IN COMBINATION WITH POLATUZUMAB VEDOTIN IN PATIENTS WITH B-CELL NON-HODGKIN LYMPHOMA
The purpose of this study is to test the safety of mosunetuzumab at different dose levels when given in combination with polatuzumab vedotin and to ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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CDA Diefenbach Medpace Protocol ID ME-522-001 titled: A Phase 1 Open-label Study of Voruciclib in Subjects with Relapsed and/or Refractory B Cell Malignancies After Failure of Prior Standard Therapies
If you have been diagnosed with a B cell type cancer that has relapsed (come back) or is refractory (did not respond to previous treatment ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase I/II Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma
If you have been diagnosed with mantle cell lymphoma that has relapsed or refractory (lymphoma that has either come back or progressed on treatment), you ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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AN OPEN-LABEL MULTICENTER PHASE l/1B TRIAL EVALUATING THE SAFETY ANDPHARMACOKINETICS OF ESCALATING DOSES OF BTCT4465A AS A SINGLE AGENT ANDCOMBINED WITH ATEZOLIZUMAB IN PATIENTS WITH RELAPSED OR REFRACTORYB-CELL NON-HODGKIN S LYMPHOMA AND CHRONIC LYMPHOCYTIC LEUKEMIA
If you have been diagnosed with non-Hodgkin s lymphoma (NHL) or chronic lymphocytic leukemia (CLL) that relapsed after previous treatment(s), did not respond to ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase 1 Study of TJ011133 Administered Alone or in Combination with Pembrolizumab or Rituximab in Subjects with Relapsed/Refractory Advanced Solid Tumors and Lymphoma
The purpose of this study is to test the safety of a study drug called TJ011133 alone, and to test the safety of TJ011133 in ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A PHASE 1 STUDY OF MILADEMETAN IN COMBINATION WITH QUIZARTINIB IN SUBJECTS WITH FLT3-ITD MUTANT ACUTE MYELOID LEUKEMIA THAT ARE RELAPSED/REFRACTORY OR NEWLY DIAGNOSED AND UNFIT FOR INTENSIVE CHEMOTHERAPY
To determine the safety and tolerability of the drug combination, identification of the optimum dosing schedule, MTD, and the recommended dose for expansion cohort (RDE ...Phase
Interventional
TRIAL ROLE: Sub Investigator
