5 clinical trials found.
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Mechanistic basis for impaired B cell depletion after anti-CD20 treatment of African American with neuro-inflammatory disorders
The purpose of this research is to better understand why African Americans with Multiple Sclerosis (MS), Neuromyelitis optica (NMO), or other neuroinflammatory disorders, have fast ... -
A Phase III Randomized Double-Blind Placebo-Controlled Multicenter Study to Evaluate the Efficacy Safety Pharmacokinetics and Pharmacodynamics of Satralizumab as Monotherapy or in Addition to Baseline Therapy in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
The purpose of this study is to compare the effects, good or bad, of satralizumab with placebo alone or in combination with current treatment (baseline ... -
A pragmatic trial to evaluate the intermediate-term effects of early aggressive versus escalation therapy in people with multiple sclerosis
The purpose of this research is to identify the most appropriate treatment strategy for people with multiple sclerosis (MS), especially shortly after diagnosis when it ... -
Mesoscopic Biomarkers of Neurodegeneration and Inflammation with Diffusion MRI
The purpose of this study is to track both neurodegeneration and inflammation in multiple sclerosis (MS) disease progression by taking pictures using Magnetic Resonance Imaging ... -
Health Evaluation Allostatic Load Multiple Sclerosis (HEAL-MS)
The role of childhood adversity has yet to be examined in pediatric-onset MS, despite data demonstrating that childhood adversity has been linked to earlier age ...