17 clinical trials found.
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TRANSFORM: A 52-week Randomized Placebo-controlled Double-blind Adaptive Phase 2b/3 Trial of Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness
Calliditas Suisse SA (the Sponsor) is conducting a clinical research study to see if an experimental medicine named setanaxib, will help in the treatment of ...Phase
TRIAL ROLE: Sub Investigator
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AFFIRM: A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Effect of Seladelpar on Clinical Outcomes in Patients with Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
The purpose of this study is to evaluate the effectiveness of seladelpar on mitigating liver-related symptoms and clinical events, when compared to the placebo, in ...Phase
TRIAL ROLE: Sub Investigator
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A 52-week Double-blind Placebo-controlled Randomized Phase 3 study Intended to Determine the Effects of seladelpar on normalization of Alkaline phosphatase Levels in Subjects with Primary Biliary Cholangitis (PBC) and an Incomplete Response or Intolerance to Ursodeoxycholic Acid
The purpose of this study is to determine the effects of seladelpar on normalization of Alkaline Phosphatase Levels in Subjects with Primary Biliary Cholangitis (PBC ...Phase
TRIAL ROLE: Sub Investigator
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A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Safety Tolerability Pharmacokinetics of AHB-137 with Single Ascending Doses and Multiple Doses in Healthy Volunteers and Initial Efficacy in Chronic Hepatitis B Patients
This phase I study is designed to evaluate the safety, tolerability, and pharmacokinetics of AHB-137 in healthy participants and initial efficacy in CHB patients. A ...Phase
Accepts Healthy Volunteer
TRIAL ROLE: Sub Investigator
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A Randomised Double-blind Placebo-controlled Multicentre Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) and Fibrosis Stages F2 and F3
This Phase 3 study is conducted to evaluate Lanifibranorin adults with NASH and liver fibrosis stage 2 or 3 and consists of 2 parts: Part ...Phase
TRIAL ROLE: Sub Investigator
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A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the Treatment of Cholestatic Pruritus in Patients with Primary Sclerosing Cholangitis (VISTAS)
The purpose of this clinical research study is to learn more about the use of the study drug, volixibat, for the treatment of pruritus (itching ...Phase
TRIAL ROLE: Sub Investigator
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A Randomized Double-blind Placebo-controlled Phase 2a Study to Evaluate the Safety and Efficacy of Zetomipzomib (KZR-616) in Patients with Autoimmune Hepatitis
This is a Phase 2a, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and efficacy of zetomipzomib in patients with AIH who have ...Phase
TRIAL ROLE: Sub Investigator
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Randomized Double-Blind Placebo-Controlled Study to Evaluate the Effects of EP547 in Subjects with Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis
Intense. Unrelenting. Distressing. Itching.
If you have itch due to liver disease, consider participating in pruritus research. The PACIFIC study is testing an investigational drug ...Phase
TRIAL ROLE: Sub Investigator
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A Phase II Multicenter Double-Blind Randomised Placebo-Controlled Study and Open-Label Long Term Extension to Evaluate the Safety and Efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC)
This study will evaluate the effects of elafibranor (the study drug) in participants with Primary Sclerosing Cholangitis (PSC). PSC is a rare disease of the ...Phase
TRIAL ROLE: Sub Investigator
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A Randomized Double-Blind Placebo-Controlled Phase 2 Study Comparing the Efficacy and Safety of Tirzepatide versus Placebo in Patients with Nonalcoholic Steatohepatitis (NASH)
This study will examen whether the investigational drug, tirzepatide, is safe and able to help study participants with nonalcoholic steatohepatitis (NASH). “Investigational” means that the ...Phase
TRIAL ROLE: Sub Investigator
