11 clinical trials found.
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A Multicenter Open-Label Extension Study to Assess the Long-Term Safety Tolerability and Efficacy of Bimekizumab in the Treatment of Subjects with Active Psoriatic Arthritis
The purpose of this study is to help us understand how safe, effective and tolerable an investigational new drug called bimekizumab (bye-me-key-zoo-mab) is for a ... -
A multipart exploratory study to evaluate splenic nerve stimulation in patients with rheumatoid arthritis.
The purpose of this research study is to test an investigational device and its accessories to help determine whether this study device may be used ... -
A Phase 3b Multicenter Randomized Double-blind Placebo-controlled Study Evaluating the Efficacy and Safety of Subcutaneously Administered Guselkumab in Improving the Signs and Symptoms and Inhibiting Radiographic Progression in Participants with Activ
The purpose of this study is to see if guselkumab is safe and useful for treating patients with active psoriatic arthritis (PSA). Guselkumab is a ... -
A randomized double-blind placebo-controlled study of ALPN-101 in systemic lupus erythematosus.
Lupus is a disease that occurs when your body's immune system is active in a way that can injure your own healthy tissues and ... -
A Randomized Controlled Pragmatic Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
The purpose of this research study is to help determine the safety of a drug called baricitinib. Baricitinib is a type of medicine called a ... -
A randomized parallel-group double-blind placebo-controlled multicenter Phase III trial to investigate the efficacy and safety of secukinumab 300 mg administered subcutaneously versus placebo both in combination with a glucocorticoid taper regimen i
The purpose of this research study is to demonstrate if secukinumab 300 mg and secukinumab 150 mg administered as an injection under the skin is ... -
A Phase 2b Double-Blind Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
The purpose of this research study is to see how safe an investigational drug, peresolimab, is and how well it will work to help people ... -
A Multicenter Randomized Double-Blind Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Non-Biologic Lupus Standard of Care
The purpose of the study is to investigate if the investigational study drug BIIB059 can reduce disease activity and inflammation in people with active systemic ... -
A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (POETYK-SLE-2)
This study is a double-blinded 52-week clinical trial to evaluate the efficacy and safety of deucravacitinib in adult participants with active Systemic Lupus Erythematosus (SLE ... -
A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized Double-Blind Placebo-Controlled Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous
The overall objective of this study is to evaluate the efficacy and safety of BIIB059 compared to placebo in participants with active SCLE and/or ...