Displaying 56 (all) recruiting clinical trials.
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A Phase 1 Study of GC012F a Chimeric Antigen Receptor T-cell (CAR T) Therapy Targeting CD19 and B-cell Maturation Antigen (BCMA) in Early-Line Treatment in Subjects with Multiple Myeloma
This is a Phase 1 study testing if the study medicine AZD0120 (Chimeric Antigen Receptor T-cell (CAR T) Therapy) is safe, effective, and has fewer ...
Phase
Interventional
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A PHASE 1B/2 PAN-TUMOR OPEN-LABEL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF IFINATAMAB DERUXTECAN (I-DXD) IN SUBJECTS WITH RECURRENT OR METASTATIC SOLID TUMORS (IDeate-Pantumor02)
This is a global, multicenter, pan-tumor, open-label, single-treatment arm, parallel-cohort, Phase 1b/2 study of I-DXd in subjects with recurrent or metastatic solid tumors previously ...Phase
Interventional
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A Phase 1b Trial of ZEN003694 (ZEN-3694) with Pembrolizumab and Nab-Paclitaxel in Patients with Metastatic Triple-Negative Breast Cancer
This is a phase 1b study testing whether the study medicine ZEN003694 (BET bromodomain inhibitor), together with pembrolizumab (immunotherapy) and nab-paclitaxel (standard chemotherapy), works well ...
Phase
Interventional
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A PHASE I FIRST-IN-HUMAN OPEN-LABELTRIALTO INVESTIGATE THE SAFETY TOLERABILITY PHARMACOKINETICS AND PRELIMINARY ANTITUMOR ACTIVITY OF SIM0500 A HUMANIZE GPRC5D-BCMA-CD3 TRISPECIFIC ANTIBODY IN PARTICIPANTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA
This is a clinical trial that aims to test the effectiveness and how the body processes a drug called SIM0500 in adult patients with relapsed ...
Phase
Interventional
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A Phase 1 Trial Investigating LY4101174 an Antibody-Drug Conjugate Targeting Nectin-4 in Participants with Recurrent Advanced or Metastatic Solid Tumors
This is a study looking at a new medicine called LY4101174. The study team wants to see if it has few effects and how well ...
Phase
Interventional
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A Molecularly Driven Phase 1b Dose Escalation and Dose Expansion Study of the DNA-PK Inhibitor Peposertib (M3814) in Combination with the ATR Inhibitor M1774
This study tests the effectiveness of two drugs, peposertib (M3814) and M1774, in patients with advanced solid tumors who have certain genetic changes or signs ...
Phase
Interventional
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ComboMATCH Treatment Trial E5: A Randomized Phase II Study of AMG 510 (Sotorasib) with or without Panitumumab in Advanced Solid Tumors
This study will have two groups of patients to test the combination of AMG 510 (Sotorasib) and panitumumab for advanced cancers with KRAS G12C mutations ...
Phase
Interventional
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Phase I Pilot study of Endoscopic Ultrasound guided RFA in advanced pancreatic cancer
This study is testing how using a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) together with chemotherapy before surgery (Neoadjuvant) can be safe and effective ...
Phase
Interventional
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A Phase 1 Study of Nivolumab in Combination with ASTX727 in B-cell lymphoma (NHL or HL) with an Expansion Cohort in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
This study has two parts: first, the study team wants to figure out the amount with few side effects of two drugs, nivolumab and ASTX727 ...
Phase
Interventional
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Open-Label Multicenter Phase 1 Study to Assess the Safety of P-CD19CD20-ALLO1 in Subjects with Selected Relapsed/Refractory B cell Malignancies
This Phase 1, multi-center, open-label, dose escalation study will enroll and treat approximately 120 adult subjects with relapsed/refractory DLBCL NOS (including DLBCL arising from ...Phase
Interventional
