Displaying 25 (all) recruiting clinical trials.
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A Phase 1 First in human Dose Escalation and Expansion Multicenter Study of XMT-1660 in Participants with Solid Tumors
The proposed first-in-human study of XMT-1660 will be a Phase 1, open-label trial of XMT-1660 in previously treated participants with metastatic TNBC, HR+/HER2- or ...Phase
Interventional
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Melanoma Margins Trial (MelMarT): A Phase III Multi-Centre Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
This study will determine whether there is a difference in disease free survival for patients treated with either a 1cm excision margin or 2cm margin ...Phase
Interventional
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A Multicenter Randomized Double-blind Placebo-controlled Parallel Arm Study to Assess the Safety and Efficacy of a Single Treatment of BOTOX Followed by an Optional Open-Label Treatment with BOTOX in Female Subjects with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
The objectives of the study are to demonstrate the safety and efficacy of BOTOX 100 U in reducing bladder pain compared to placebo in adult ...Phase
Interventional
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A Phase 1/2a Multicenter Open-Label First in Human Study to Assess the Safety Tolerability Pharmacokinetics and Preliminary Antitumor Activity of DB-1303 in Patients with Advanced/Metastatic Solid Tumors
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303 in subjects with advanced solid tumors that ...Phase
Interventional
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A Phase 2 Study of XmAb 20717 in Patients With Selected Gynecological Malignancies and High-Risk Metastatic Castration-Resistant Prostate Cancer
This is a Phase 2, multicenter, two-stage, open-label, parallel-group study designed to evaluate the efficacy and safety of XmAb20717 in patients with selected advanced gynecologic ...Phase
Interventional
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Effects of Implementing a Post-surgical Dietary and Lifestyle Protocol on Uterine Fibroid Recurrence
This prospective pilot study will enroll asymptomatic, post-surgical patients who underwent a laparoscopic, open, robotic myomectomy, or other procedures ie Sonata, Accessa for fibroid removal ...Phase N/A Interventional
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A Phase 1b/2 Open-label Umbrella Study to Evaluate Safety and Efficacy of Elacestrant in Various Combinations in Patients with Metastatic Breast Cancer (ELEVATE)
This is a multicenter, Phase 1b/2 trial. The Phase 1b part of the trial aims to determine the RP2D of elacestrant when administered in ...Phase
Interventional
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Heart Attack Research Program (HARP)
The Heart Attack Research Program (HARP) is a multi-discipline and mutli-center study that incorporates clinical and basic science and population health to investigate mechanisms of ...Phase N/A
Non-Interventional
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CivaTech Oncology:Feasibility study to treat lung cancer with the permanently implantable LDR CivaSheet
This is a feasibility study to determine the usefulness of a brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration ...Phase
Interventional
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Site for WUH: Effect of storage on breast milk cytokines in premature infants in the first 4 weeks after birth
Site for The Objective of this study is to evaluate the effect of storage of freshly expressed breast milk at different temperatures (Room air, 4 ...Phase N/A Non-Interventional
