165 "Healthy volunteers" clinical trials found.
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A single-center longitudinal study of the diagnosis clinical course risk factors causes and treatment of cognitive impairment in aging Alzheimer s disease (AD) and related disorders
The purpose is to study the diagnosis, clinical course, risk factors, causes and treatment of cognitive impairment in aging, Alzheimer’s disease (AD) and related ...Phase N/A
Non-Interventional
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Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A prospective multicenter randomized controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with mitral regurgitation
This is a prospective, multicenter, randomized, parallel-group study to compare the safety and effectiveness of the PASCAL System to the MitraClip System for reduction of ...Phase N/A
Interventional
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Investigating auditory processing in the users of auditory brainstem and cochlear implants
This is a basic investigational research study conducted with hearing impaired adults and children who use cochlear implant or auditory brainstem implant (ABI) devices. The ...Phase N/A Non-Interventional
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DISCOVER: A single-site double-blind placebo-controlled randomized mechanistic crossover trial to assess the influence of boDy weIght on aSpirin-triggered speCialized prO-resolVing mEdiatoRs
This study employs a placebo-controlled randomized cross-over design to investigate the impact of body weight and aspirin dose on levels of specialized pro-resolving lipid mediators ...Phase
Interventional
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A Prospective Randomized Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement : The PROGRESS Trial
This is a randomized 1:1 trial in which subjects will receive transcatheter aortic valve replacement (TAVR) with the SAPIEN 3/SAPIEN 3 Ultra transcatheter ...Phase N/A Interventional
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Predicting poor vaccine responders to Hepatitis B vaccination
Hepatitis B vaccines are indicated broadly for the prevention of hepatitis B infection, yet the vaccine is not uniformly effective in all individuals. We need ...Phase
Interventional
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Dentatorubral-Pallidoluysian Atrophy Natural History and Biomarkers Study (DRPLA NHBS)
This is a prospective, limited collection of retrospective information, longitudinal, multi-national, multi-center study, observational, confirmed DRPLA-mutation carrier and a volunteer control group.Phase N/A Non-Interventional
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A Placebo-Controlled Efficacy in iNPH Shunting (PENS) Trial
This is a multicenter, randomized, blinded, placebo-controlled study of patients with suspected idiopathic normal pressure hydrocephalus (iNPH). Using FDA-approved technology, we propose a prospective randomized ...Phase N/A Interventional
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A computational approach to optimal deactivation of cochlear implant electrodes
The goal of the present study is to use computationally driven models of speech understanding in CI users to guide the search for which combination ...Phase N/A Interventional
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CP-CGMH: Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring with Mobile Health: Improving Outcomes for Older Adults with Mild Cognitive Impairment
The purpose of this study is to examine the acceptability of continuous glucose monitoring (CGM) and identify the key domains of a future care partner-assisted ...Phase
Interventional
