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Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults (EXIT CJS)
This study seeks to meaningfully address the U.S. opioid epidemic by comparing the effectiveness of two medications used to treat opioid use disorder, extended-release ... -
T2 Alpha Femur Antegrade PF
This investigation is a prospective, multicenter clinical investigation designed to examine the safety and efficacy/performance of the Femoral Nail PF of the T2 Alpha ... -
A Post-Market Clinical Evaluation of the Treatment of Femur Fractures with the Femoral Nail Greater Trochanter (GT) of the T2 Alpha Femur Antegrade GT/PF Nailing System
This prospective, multi-center, clinical investigation, designed to examine the safety and efficacy/performance of the Femoral Nail GT of the T2 Alpha Femur Antegrade GT ... -
A Prospective multicenter study to examine the influence of repairing the sub-scapularis on outcomes after reverse arthroplasty: A randomized controlled trial.
Determine how repairing the subscapularis vs. not repairing the subscapularis when subjects are implanted with the AltiVate Reverse® Shoulder System for reverse total shoulder arthroplasty ... -
A Multicenter Randomized Double-Blind Placebo-Controlled Non-inferiority Crossover Study Evaluating the Safety and Immunogenicity of the Herpes Zoster Subunit Vaccine in Patients with Systemic Lupus Erythematosus
This randomized, double-blind, placebo-controlled, non-inferiority crossover study will evaluate the HZ/su vaccine in SLE patients in order to evaluate safety and immunogenicity in patients ... -
DISCOVER: A single-site double-blind placebo-controlled randomized mechanistic crossover trial to assess the influence of boDy weIght on aSpirin-triggered speCialized prO-resolVing mEdiatoRs
This study employs a placebo-controlled randomized cross-over design to investigate the impact of body weight and aspirin dose on levels of specialized pro-resolving lipid mediators ... -
Predicting poor vaccine responders to Hepatitis B vaccination
Hepatitis B vaccines are indicated broadly for the prevention of hepatitis B infection, yet the vaccine is not uniformly effective in all individuals. We need ... -
Depression treatment and A dynamics: A study of Alzheimer s disease risk (ABD Study)
The study will use a randomized 8-week double-blind placebo controlled parallel trial using escitalopram to test the associations between depressive symptoms (captured by the MADRS ...