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Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
We propose a rapid and robust approach for the quantitative multi-compartment assessment of knee cartilage using magnetic resonance imaging without using either exogenous contrast agent ... -
Relationship between the ocular microbiome and pseudoexfoliation syndrome/glaucoma and cataracts
Observational study to determine the microbiome structure of the eye, mouth, and skin of subjects with pseudo exfoliation syndrome, pseudoexfoliation glaucoma, and cataracts before and ... -
Platelet and Endothelial Dysfunction in Psoriasis
Background: Psoriasis is a common chronic inflammatory skin disease associated with an ~50% increased risk of cardiovascular disease (CVD) compared to matched controls. The influence ... -
Chronic Pain and Postoperative Cognitive Function in the Elderly: a Prospective Observational Study
To assess the possible interrelation between pre-operative chronic pain and postoperative cognitive dysfunction (POCD) in the elderly, we plan to enroll patients undergoing planned surgery ... -
Brain Effects of Lifetime Racial/Ethnic Discrimination on the LC-NE Function and the Risk for Alzheimer's Disease
The current biomarker classification system (i.e., the ATN model) may not fully account for racial disparity and can’t explain the increased prevalence in ... -
Technical Development Observational study for Microstructure MRI
Newly developed imaging protocols will conform to scanner safety requirements and any applicable FDA standards. The output of the scanning session will be in the ... -
Understanding the Lived Experience of Couples Across the Trajectory of Dementia
This multi-site, observational study will focus on the experience of older couples and the impact of Alzheimer's disease or a related dementia on health ... -
Early Signs: digital phenotyping to identify digital biomarkers for predicting burnout and cognitive functioning in ED clinicians
Our overall goal is to enhance the ability to assess and understand the development of burnout amongst ED staff using objective, ecologically valid, economical, and ... -
Models of speech perception by users of auditory neural prostheses-Project 1
The first specific aim of the proposed research is to develop mathematical models of phoneme and word identification for individual CI users. To achieve this ... -
Neural markers of risk for anxiety in infancy
This study will examine associations between brain development and several behavioral risk markers for anxiety. This work will provide novel data on the neurodevelopmental mechanisms ...